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Search Results for " VEGFR inhibitor "

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216

阻害剤

天然化合物

ライブラリー

カタログ番号	製品名	別名	ターゲット
T9979	VEGFR-2-IN-29		VEGFR
	VEGFR-2-IN-29 is a VEGFR2 inhibitor.		VEGFR
T21593	AAL-993		VEGFR
	AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...		VEGFR
T12598	Pz-1		VEGFR , c-RET
			VEGFR , c-RET
T9724	VEGFR2-IN-2		Others
	VEGFR2-IN-2 has anti-inflammatory and analgesic activities.		Others
T2056	VEGFR-2-IN-5	2, 4-Pyrimidinediamine with linker,UNC0064-12,2,4-Pyrimidinediamine with linker	VEGFR
	VEGFR-2-IN-5 (UNC0064-12), multikinase inhibitor and has a -NH2 terminal linker for further synthesis.		VEGFR
TQ0321	BIBF 1202		VEGFR
	BIBF 1202 is a VEGFR2 kinase inhibitor (IC50: 62 nM).		VEGFR
T2446	KI8751		EGFR , VEGFR , FGFR , PDGFR , c-Kit
	KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.		EGFR , VEGFR , FGFR , PDGFR , c-Kit
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T22349	JNJ-38158471	CS-2660	VEGFR , c-RET , c-Kit
	JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.		VEGFR , c-RET , c-Kit
T4026	SU5408	VEGFR2 Kinase Inhibitor I	VEGFR
	SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.		VEGFR
T6012	SAR131675	SAR 131675	VEGFR
	SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.		VEGFR
T11520	GW806742X		MLK , VEGFR
	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.		MLK , VEGFR
TP1474	LXW7		Integrin
	LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-pepti...		Integrin
T2419	BMS-794833		VEGFR , c-Met/HGFR
	BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378.		VEGFR , c-Met/HGFR
TQ0041	Ningetinib Tosylate		VEGFR , c-Met/HGFR , TAM Receptor
	Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.		VEGFR , c-Met/HGFR , TAM Receptor
T2642	PD173074		Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for FGFR1 than PDGFR and c-Src.		Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
T5475	ZD-4190		EGFR , VEGFR
	ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pathways, utilized in cancer treatment.		EGFR , VEGFR
T16975	TAK-593		VEGFR , PDGFR
	TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).		VEGFR , PDGFR
T4288	HVEGF-IN-1		VEGFR
	hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.		VEGFR
T1656	Vandetanib	ZD6474	Apoptosis , EGFR , VEGFR , Autophagy
	Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.		Apoptosis , EGFR , VEGFR , Autophagy
T2064	Semaxinib	SU5416	VEGFR
	Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the...		VEGFR
T3566	SU5205	SU 5205	VEGFR
	SU5205 is a VEGFR2 inhibitor.		VEGFR
T5349	SCR-1481B1	c-Met inhibitor 2	VEGFR , c-Met/HGFR
	SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor		VEGFR , c-Met/HGFR
T9928	Ranibizumab		VEGFR
	Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n...		VEGFR
T3691	(Rac)-SAR131675	SAR131675	VEGFR
	(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is h...		VEGFR
T2656	Fruquintinib	HMPL-013	VEGFR
	Fruquintinib (HMPL-013) is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities.		VEGFR
T6036	Brivanib	BMS-540215	EGFR , VEGFR , FGFR , Autophagy
	Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.		EGFR , VEGFR , FGFR , Autophagy
T1754	ZM 306416	CB 676475	VEGFR , Bcr-Abl , Src
	ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).		VEGFR , Bcr-Abl , Src
T23504	VEGFR-IN-1	VEGFR Tyrosine Kinase Inhibitor II	Others
	VEGFR inhibitor		Others
T6996	SU 5402	SU5402	VEGFR , FGFR , PDGFR
	SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.		VEGFR , FGFR , PDGFR
T3599	BFH772	BFH-722	VEGFR
	BFH772, a structure analogue of BAW2881, is a potent and selective VEGF inhibitor. BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. BFH772 inhibits the ligand induced autophosphorylation ...		VEGFR
T15185	Lucitanib	E-3810	VEGFR , FGFR
	Lucitanib (E-3810) is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively).		VEGFR , FGFR
T6517	Golvatinib	E-7050	VEGFR , c-Met/HGFR
	Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic ...		VEGFR , c-Met/HGFR
T9473	4SC-203		FLT
	4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG...		FLT
T7945	SU14813		VEGFR , PDGFR , c-Kit
	SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).		VEGFR , PDGFR , c-Kit
T5466	Tyrosine kinase-IN-1		VEGFR , FGFR , FLT , PDGFR
	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）		VEGFR , FGFR , FLT , PDGFR
T4425	JK-P3		VEGFR
	JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format...		VEGFR
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T3569	SU5214	SU 5214	VEGFR , Tyrosinase
	SU5214 is a modulator of tyrosine kinase signal transduction.		VEGFR , Tyrosinase
TQ0317	R1530	R-1530,R 1530	VEGFR , FGFR , FLT , PDGFR
	R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.		VEGFR , FGFR , FLT , PDGFR
T7611	ODM-203		VEGFR , FGFR
	ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity		VEGFR , FGFR
T13238	Tyrphostin AG1433	SU1433,AG1433	VEGFR , PDGFR
			VEGFR , PDGFR
T2415	PP121		Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck
	PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM).		Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck
T8496	MAZ51		Apoptosis , VEGFR
	MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.		Apoptosis , VEGFR
T6166	Telatinib	Bay 57-9352	VEGFR , PDGFR , c-Kit
	Telatinib (Bay 57-9352) is an effective inhibitor of VEGFR2/3, c-Kit, and PDGFRα. The IC50s of Telatinib forVEGFR2/3, c-Kit and PDGFRα are 6 nM/4 nM, 1 nM, and 15 nM, respectively.		VEGFR , PDGFR , c-Kit
T2288	Motesanib	AMG 706	VEGFR , c-Kit
	Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-deriv...		VEGFR , c-Kit
T17219	Vatalanib free base		VEGFR
	Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM).		VEGFR
T3641	NVP-BAW2881	BAW2881	Raf , VEGFR , Bcr-Abl
	NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.		Raf , VEGFR , Bcr-Abl
TQ0021	Ningetinib	CT-053,CT053PTSA	VEGFR , c-Met/HGFR , TAM Receptor
	Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.		VEGFR , c-Met/HGFR , TAM Receptor
T3570	SU4312	SU 4312,NSC 86429	VEGFR , PDGFR
	SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...		VEGFR , PDGFR

Compounds

Target: VEGFR, c-RET

Synonym: 2, 4-Pyrimidinediamine with linker,UNC0064-12,2,4-Pyrimidinediamine with linker

Target: EGFR, VEGFR, FGFR, PDGFR, c-Kit

Target: VEGFR, c-RET, c-Kit

SU5408

T4026

Synonym: VEGFR2 Kinase Inhibitor I

Target: VEGFR, c-Met/HGFR

Ningetinib Tosylate

TQ0041

Synonym:

Target: VEGFR, c-Met/HGFR, TAM Receptor

PD173074

T2642

Synonym:

Target: Apoptosis, EGFR, VEGFR, FGFR, IGF-1R, Src

ZD-4190

T5475

Synonym:

Target: EGFR, VEGFR

TAK-593

T16975

Synonym:

Target: VEGFR, PDGFR

Target: Apoptosis, EGFR, VEGFR, Autophagy

Synonym: c-Met inhibitor 2

Target: VEGFR, c-Met/HGFR

Target: EGFR, VEGFR, FGFR, Autophagy

ZM 306416

T1754

Synonym: CB 676475

Target: VEGFR, Bcr-Abl, Src

VEGFR-IN-1

T23504

Synonym: VEGFR Tyrosine Kinase Inhibitor II

Target: VEGFR, FGFR, PDGFR

Target: VEGFR, FGFR

Golvatinib

T6517

Synonym: E-7050

Target: VEGFR, c-Met/HGFR

Target: VEGFR, PDGFR, c-Kit

Tyrosine kinase-IN-1

T5466

Synonym:

Target: VEGFR, FGFR, FLT, PDGFR

Target: VEGFR, p38 MAPK, JAK, Src

SU5214

T3569

Synonym: SU 5214

Target: VEGFR, Tyrosinase

R1530

TQ0317

Synonym: R-1530,R 1530

Target: VEGFR, FGFR, FLT, PDGFR

ODM-203

T7611

Synonym:

Target: VEGFR, FGFR

Tyrphostin AG1433

T13238

Synonym: SU1433,AG1433

Target: VEGFR, PDGFR

PP121

T2415

Synonym:

Target: Apoptosis, VEGFR, Bcr-Abl, PDGFR, Src, mTOR, Hck

MAZ51

T8496

Synonym:

Target: Apoptosis, VEGFR

Telatinib

T6166

Synonym: Bay 57-9352

Target: VEGFR, PDGFR, c-Kit

Motesanib

T2288

Synonym: AMG 706

Target: VEGFR, c-Kit

Target: Raf, VEGFR, Bcr-Abl

Ningetinib

TQ0021

Synonym: CT-053,CT053PTSA

Target: VEGFR, c-Met/HGFR, TAM Receptor

SU4312

T3570

Synonym: SU 4312,NSC 86429

Target: VEGFR, PDGFR

カタログ番号	製品名	別名	ターゲット
T8213	Isolinderalactone		NOS , STAT
	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.		NOS , STAT
T17280	(Z)-Guggulsterone		Apoptosis , VEGFR , Akt
	(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.		Apoptosis , VEGFR , Akt
T4A2456	Gamabufotalin	Gamabufagin	COX
	1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.		COX
T2906	Tanshinone IIA	Tanshinone B,Dan Shen ketone	VEGFR
	Tanshinone IIA (Tanshinone B)(Tanshinone B) is the diterpene quinone in Danshen, which is utilized in the treatment of cardiovascular and inflammatory.		VEGFR
T3S0153	Xanthatin		Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial
	1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr...
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T7203	Oglufanide	L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR , HCV Protease , Endogenous Metabolite
	Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).		VEGFR , HCV Protease , Endogenous Metabolite
T1152	Albendazole	SKF-62979	HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
	Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T13108	Pamufetinib	H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115	VEGFR , c-Met/HGFR
	Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively).		VEGFR , c-Met/HGFR
T1205	Chloramphenicol	Chlornitromycin,Levomycetin,Chloromycetin	ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
TWA2417	Sodium taurocholate	Taurocholate Sodium	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and...		Others
T14055	5Z-7-Oxozeaenol	FR148083,L783279,LL-Z 1640-2	VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src
	5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is ...		VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src
TN4343	Jaceidin	5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone,Quercetagetin 3,3',6-trimethyl ether,Jaceidine	VEGFR , Antioxidant
			VEGFR , Antioxidant

天然物製品

Target: Apoptosis, VEGFR, Akt

Synonym: Tanshinone B,Dan Shen ketone

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon

Target: BCL, Caspase, PI3K

Oglufanide

T7203

Synonym: L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Albendazole

T1152

Synonym: SKF-62979

Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite

Pamufetinib

T13108

Synonym: H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115

Target: VEGFR, c-Met/HGFR

Chloramphenicol

T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Sodium taurocholate

TWA2417

Synonym: Taurocholate Sodium

Target: Others

5Z-7-Oxozeaenol

T14055

Synonym: FR148083,L783279,LL-Z 1640-2

Target: VEGFR, FLT, MEK, MAPK, PDGFR, Antibiotic, Src

Jaceidin

TN4343

Synonym: 5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone,Quercetagetin 3,3',6-trimethyl ether,Jaceidine

Target: VEGFR, Antioxidant

カタログ番号	製品名
L1610	FDA-Approved Kinase Inhibitor Library	263 compounds
	A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L1600	Kinase Inhibitor Library	2720 compounds
	A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;

ライブラリー

FDA-Approved Kinase Inhibitor Library

L1610

Compounds: 263

Kinase Inhibitor Library

L1600

Compounds: 2720